| Synthesis of Admantane Substituted Spiro 1,2,4-Trioxanes Using Simple and Cheap Starting Material |
| LALIT KUMAR*, NIRANJAN KAUSHIK, ANUJ MALIK and PRADEEP KUMAR |
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences
Manipal Academy of Higher Education, Manipal-576 119, India
E-mail: pradeep_alpine@yahoo.co.in |
| Abstract
Spiro 1,2,4-trioxane are synthetic derivative of artemisinin (1,2,4-
trioxane is supposed to be a pharmacophore of artemisinin) which is a
well known antimalarial drug from leaves of Artemisia annua found in
China. Spiro 1,2,4-trioxane substituted with admantane and its 4 different
derivatives were synthesized using well standardized method. These
compounds were purified by simple column chromatography and successfully
analyzed using 1H NMR, IR and FAB-MS techniques. |
| Keywords
1,2,4-Trioxane, Artemisinin, NMR, IR, FAB-MS. |
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