Simultaneous Estimation of Residual Solvents (Isopropyl Alcohol and Dichloromethane) in Dosage Form by GC-HS-FID
Praveen Kumar Baliyan*, R.P. Singh and Saurabh Arora

Analytical Division, Arbro Pharmaceuticals Ltd.
4/9, Kirti Nagar Industrial Area, New Delhi-110 015, India
E-mail: praveenbaliyanraj@yahoo.co.in

Abstract

A simple and sensitive method for the determination of isopropyl alcohol and dichloromethane as residual solvent was developed and validated on gas liquid chromatography with headspace sampler fitted with flame ionization detector (GC-HS-FID). The carrier gas was helium and separation was carried out on Elite-624 (30 meter, 0.53 mm ID, 3μm df) capillary column consisting of 6 % cyanopropylphenyl - 94 % dimethyl polysiloxane stationary phase. The retention time for isopropyl alcohol and dichloromethane were 10.8, 11.4 min, respectively.

Keywords

Isopropyl alcohol, Dichloromethane, GC-HS-FID.
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  • Asian J. Chem. /
  •  2009 /
  •  21(3) /
  •  pp 1739-1746