Synthesis of Some 4'-Amino Chalcones and their Antiinflammatory and Antimicrobial Activity
Y. Rajendra Prasad*, A. Srinivasa Rao and R. Rambabu

Pharmaceutical Chemistry Division, AU College of Pharmaceutical Sciences
Andhra University, Visakhapatnam-530 003, India
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A series of some 4'-amino chalcones were synthesized by Claisen- Schmidt condensation of 4-amino acetophenone with various substituted aromatic aldehydes. The synthesized chalcones were characterized by IR, 1H NMR and elemental analyses. When these chalcones (3a-h) were evaluated for antiinflammatory, antibacterial and antifungal activities, some of them found to possess significant biological activity when compared to standard drugs.


Chalcone, Synthesis, Antiinflammatory, Antimicrobial activity.
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  • Asian J. Chem. /
  •  2009 /
  •  21(2) /
  •  pp 907-914