| Alkaloids and Carboxylic Acids from Piper nigrum |
| G.C.L. Ee*, S.K. Lim, C.M. Lim and K. Dzulkefly |
Chemistry Department, Faculty of Science, University Putra Malaysia
43400, Serdang, Selangor, Malaysia
Fax: (603)89435380; Tel: (603)89466785; E-mail: gwen@fsas.upm.edu.my |
| Abstract
Detailed chemical studies were carried out on the roots
of Piper nigrum. Six alkaloids and four carboxylic acids were
isolated and identified from this study. The alkaloids were
piperolactam A (1), piperolactam D (2), cepharadione A (3),
piperine (4), sylvamide (5) and 2,4-tetradecadienoic acid
isobutyl amide (6). The carboxylic acids were tetracosanoic
acid, p-hydroxy-m-methoxycinnamate ester (7), 3,4-methylenedioxycinnamic
acid (8), 2-butenedioic acid, mono-(2-methylpropyl)
ester (9) and 3,4-methylenedioxy benzoic acid (10).
Larvicidal assays on Aedes aegypti were carried out on the
crude extracts of these plants as well as the pure compounds.
The larvae were found to be susceptible to some of these
extracts and compounds. This paper reports the isolation and
characterization of these compounds as well as bioassay data.
This is the first report on the presence of piperolactam A (1),
piperolactam D (2) cepharadione A (3) and sylvamide (5) in
Piper nigrum. |
| Keywords
Alkaloids, Carboxylic acid, Piper nigrum, Larvicidal. |
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