| Antimicrobial and Antimycobacterial Activity of Some Quinoxalines 'N' Bridgehead Heterocycles |
| S. GANAPATY†, P. RAMALINGAM* and CH. BABURAO |
Department of Pharmaceutical and Medicinal Chemistry, Siddharth Institute of Pharmacy
Nalanda Educational Campus, Kantepudi, Sattenapalli (M), Guntur-522 438, India
E-mail: rammpharm@rediffmail.com |
| Abstract
Quinoxalin-2,3-diones (1) on treatment with o-phenylenediamine
afforded 6,11-dihydro-5,6,-11,12-tetraazanaphthacene
(3). 2,3-Dichloroquinoxaline (2) on condensation with anthranilic
acid, o-phenylenediamine and sodium azide yielded
bis[quinazolino(3,2a)quinoxaline]-11,18-diones (4), bis[benzimidazolo(
1,2a)quinoxaline] (5) and bis-[1,2,3,4-tetrazolo
(1,5a)quinoxaline] (6), respectively. The structures have been
established by IR, mass spectral and elemental analysis. These
compounds have been evaluated for their antibacterial, antifungal
and antitubercular activity. |
| Keywords
Bridgehead quinoxaline, Antimicobaterial. |
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