Synthesis and Antitumor activity of N1-(3-Pyridoyl)- 3-Methyl-4-(Substituted Azo) Pyrazol-5-Ones

C. P. Singh* and Archana Singh
Chemical Laboratory, Sahu Jain College, Najibabd-246 763, India

A series of N1-(3-pyridoy)-3-methyl-4-(substituted azo) pyrazol-5-ones have been synthesised by the reaction of substituted azo ethyl-3-oxobutyrates with 3-pyridoylhydrazine, using glacial acetic acid as condensing agent. All compounds were evaluated against the Lymphoid leukemia L-1210 tumor system in mice. Some of them showed significant antitumor activity.


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  • Asian J. Chem. /
  •  1989 /
  •  1(3) /
  •  pp 294-296