Visible Spectrophotometric Determination of Ceftriaxone Sodium in Vials
K.S. LAKSHMI*, K. ILANGO, N. NITHYA MATHI, S. BALAJI, D. KIBE VICTOR WATHUGI and A.V. SATISH KUMAR

Department of Pharmaceutical Analysis, S.R.M. College of Pharmacy
Kattankulathur-603 203, India
E-mail: kslakshmi13@sify.com

Abstract

A rapid, sensitive and simple spectrophotometric method is developed for the estimation of ceftriaxone sodium. It is based on the reaction with 3-methyl-2-benzothiazoline hydrazone hydrochloride and ferric chloride to form a green coloured chromogen with the absorption maximum at 628 nm. The colour obeyed Beer’s law in the concentration range of 10-50 μg/mL. When pharmaceutical preparations were analyzed, the results obtained are in good agreement with the labelled amounts.
Keywords

Ceftriaxone sodium, Spectrophotometric determination.
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  • Asian J. Chem. /
  •  2007 /
  •  19(4) /
  •  pp 2517-2520