Variations in the Physico-chemical Parameters of Some 5a and 5b Substituted Barbiturate Derivatives
RAKESH RAY† , S. HARI KRISHNA, J.D. SHARMA† and S.N. LIMAYE*

Forensic Science and Chemistry, Dr. H.S. Gour University, Sagar-470 003, India
E-mail: snl222@yahoo.co.in

Abstract

The barbiturates are therapeutically used as sedative, hyponotic, anaesthetic and anticonvulsant agents. The trienolmoiety and 5-substituents regulate the biological activity regarding the lypophilicity/hydrophobicity values of barbiturates against their physico-chemical properties.
Keywords

e Barbiturates, Modelling, Hydrophobicity, Therapeutic.
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  • Asian J. Chem. /
  •  2007 /
  •  19(4) /
  •  pp 2497-2501