Studies on Trimethoxy Indan-1-yl-acetic Acids as Anti-hyperchlestrolemic Agents
MANORANJAN ADAK† and JAYANTA KUMAR GUPTA*

Division of Medicinal Chemistry, Department of Pharmaceutical Technology
Jadavpur University, Kolkata-700 032, India
E-mail: manoranjanadak@rediffmail.com

Abstract

Trimethoxy indan derivatives having (R = alkyl group) at the α-carbon atom of acetic acid moiety were synthesized and screened for anti-hypercholesterolemic activity in male albino Charles Foster rats. It was observed that percentage yield as well as pharmacological activity of synthesized compounds decreased on increasing the α-alkyl group.
Keywords

Trimethoxy indan acetic acids, Clofibrate, Antihypercholesterolemic activity.
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  • Asian J. Chem. /
  •  2007 /
  •  19(4) /
  •  pp 2559-2564