Metal Chelates of Ambidentate Ligand Cysteine and Antiulcer Drug Ranitidine

Mala Mathur, Savita Srivastava† and N.M. Srivastava*

Department of Pharmacology, Gahndhi Medical College,Bhopal-462 001, India

Abstract

The role of metal complexes in biological systems is of
paramount importance. Mixed ligand complexes, wherein one
ligand is a drug and another such an amino acid which makes part
of the living system, can affect the activity of drug to a remarkable
degree. Antiulcer drug is selected for the present study as it has
potent donor atoms/groups in its structure while amino acids act as
ambidentate ligand useful in formation of chelate rings involving
various coordination sites. Mixed ligand complexes of ranitidine,
an antiulcer drug and cysteine, an amino acid, with Mn(II), Co(II),
Cu(II) and Zn(II) have been synthesised and characterised.

Keywords

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  • Asian J. Chem. /
  •  2000 /
  •  12(2) /
  •  pp 371-374