Synthesis, Characterisation and Antimicrobial Screening of Aminobenzylated Mannich Bases of Acetamide and Urea

A.N. Mohamed Kasim* and G. Venkatesa Prabhu†

Department of Chemistry, Jamal Mohamed College, Tiruchirapalli-620 020, India

Abstract

The compound N-(1-piperidino-4-methylbenzyl)acetamide (1a),
N-( 1-piperidino-4-chlorobenzyl)acetamide (1b), N,N' -bis (1-
piperidino-4-methylbenzyl)urea (2a) and N,N'-bis (1-piperidino--
4-chlorobenzyl)urea (2b) have been synthesised by condensing
piperidine and acetamide/urea with 4-methylbenzaldehyde/4-
chlorobenzaldehyde. The compounds have been characterised on
the basis of microanalytical, IR, 1H and 13C NMR and mass spectral
data and screened for their antimicrobial activity against grampositive
and gram-negative bacteria.

Keywords

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  • Asian J. Chem. /
  •  2000 /
  •  12(2) /
  •  pp 385-388