Design, Synthesis and Biological Evaluation of Novel Thiazolidinone Derivatives

Reshma Sathyanarayana1,, Boja Poojary1,*,, B. Sukesh Kumar2,, Vasantha Kumar3,, Rajesh P. Shastry2, and Shamprasad Varija Raghu4,

1Department of Chemistry, Mangalore University, Mangalagangothri-574199, India

2Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Mangalore-575018, India

3Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire-574240, India

4Neurogenetics Lab, Department of Applied Zoology, Mangalore University, Mangalagangothri-574199, India

*Corresponding author: Tel: +91 824 2287262; E-mail:


In present study, the novel thiazolidinone derivatives were designed and synthesized. The formation of the target compounds was confirmed by the elemental analyses, FT-IR, mass spectroscopy and 1H NMR spectroscopy. These derivatives were subjected to antibacterial and antioxidant activities. The antibacterial results revealed that these derivatives were selectively active against Gram-negative Pseudomonas aeruginosa bacteria. Also, these derivatives displayed a good DPPH radical scavenging effect. Drosophila melanogaster flies were used for evaluating the toxic impact of novel thiazolidinone derivatives.


Thiazolidinone, Vanillin, Antibacterial activity, Antioxidant activity, Drosophila melanogaster.

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